Читать книгу Autologous Blood Concentrates - Arun K Garg - Страница 11

There are dozens of TGFs (including BMPs), and three of them (TGF-β1, TGF-β2, and TGF-β3) are protein growth factors that behave not only as mitogens (for cell replication) but also as morphogens (for cell differentiation).^84,85 As cell preservers, TGF-β factors serve essential functions in wound healing, from the fetus to the adult.^86–89 Like PDGFs, TGFs exert their influence in both healthy and pathologic cell activities, making their therapeutic use extremely problematic and challenging in that they often behave in opposite and even contradictory ways in both soft and hard tissues, including their roles in proliferation, migration, and differentiation^90–93 (Fig 1-7).