Читать книгу Autologous Blood Concentrates - Arun K Garg - Страница 13

IGFs are peptide hormones that have been found to promote cell growth in in vitro experiments. IGFs were also found to reduce levels of blood glucose in various tissues, hence their name. Their ability to stimulate glandular activities in humans differentiates them from other PRP growth factors. For example, IGF-1 mainly adheres to and stimulates receptors in cells of pituitary growth hormones. Most cells increase in size and number as a direct result of the synthesis and secretion of IGF-1 by tissues stimulated by growth hormones.

Growth factor production, along with growth hormone production and concentrations, wax and wane as part of the natural maturation process of humans before, during, and after pubescence, particularly for IGF-1. Liver production accounts for most IGF concentrations. IGFs have their most potent growth-stimulating effect on themselves and on nearby cells, and they (both IGF-1 and IGF-2) aid in bone cell mitosis. As an osteoblast secretion, IGF assists in osteogenesis and bone ossification via proliferation and differentiation of cells^96–98 (Fig 1-9).

FIG 1-9 Some of the roles of IGFs.

FIG 1-10 VEGF stimulates the endothelial cell, enhancing multiple phases of the angiogenic cascade.