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Efforts to standardize protocols for the clinical application of autologous platelet-derived product have often been accompanied by nonstandardized nomenclature for that product. Many researchers believe the term platelet-rich plasma is too general and incomplete, leading to confusion not only in preparation and application but also in cataloging in the scientific databases, thus hampering the flow of information in the scientific community. Other names that have been applied over the years include platelet-rich fibrin (PRF), autologous platelet-rich plasma (aPRP), platelet gel (PG), autologous platelet concentrates (APCs), preparation rich in growth factors (PRGF), platelet-derived growth factor (PDGF), platelet-leukocyte gel(PLG), concentrated growth factors (CGFs), and numerous others (Fig 1-19).

FIG 1-19 The terminology for PRP is a confusing alphabet soup of acronyms. Chapter 4 presents the names and formulations for eight configurations of PRP and the step-by-step instructions for preparing them.

A simplified terminology-classification system for platelet concentrates has been widely adopted. It consists of eight categories based on its consistency and clinical application. The researchers and clinicians who devised this classification system believe it underscores the profound potential of these products and the need for all stakeholders to learn and demonstrate their awareness of the products’ complexity. The composition and application of these other forms of PRP are detailed in the chapters of this book.

Historically, the majority of studies of the clinical efficacy of PRP did not provide sufficient information to allow their PRP preparation protocol to be reproduced. This not only added to the confusion over terminology but also made it impossible to compare the PRP products that were being tested. Several recent papers have addressed this confusion and shared ideas about how to standardize the protocol to make PRP preparation simple and straightforward, and most importantly, to obtain a consistent and effective platelet yield.^146–148 In 2017, Chahla et al published a systematic review of the clinical orthopedic literature on PRP and a call for more standardized reporting of PRP preparation protocols and composition.¹⁴⁶ Although 105 studies met the inclusion criteria for analysis, only 11 of them (10%) provided sufficient detail of their preparation protocol to allow it to be reproduced. Additionally, only 17 studies (16%) provided quantitative metrics on the composition of the PRP product they delivered to patients.