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Naming and classifying platelet derivatives

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Nearly 25 years after the earliest reports appeared, the literature on PRP for both human and veterinary medicine still lacks consensus on standardized protocols for preparing, naming, classifying, and applying platelet concentrates. PRP appears to remain the most likely term, given that plasma resuspension of any platelet concentrate is required before application.1 A high-density fibrin concentrate can facilitate cell migration and the release of cytokines. However, the number of leukocytes affects the concentrate’s wound healing ability, leading to the often contradictory results of different studies.

Table 1-1 Factors that influence the quality of platelet concentrates

Preparation step Critical factor Details
Blood collection Needle Tubing of butterfly needle Syringe/tube Lag Gauge, length, material, surface modification Diameter, length, material Materials, surface modification Distance between blood-collection space and centrifuge
Centrifuge Tube Rotator Centrifugal condition Shape, material, surface modification Swing or angle Force, duration
Other handling Pipetting Coagulation Technique, material CaCl2, thrombin, glassware
Autologous Blood Concentrates

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