Читать книгу Neurology - Charles H. Clarke - Страница 54

Zona incerta cells beside each lateral nucleus of the hypothalamus control thirst. Lesions lead to neglect of drinking. Other mechanisms contribute to osmotic homeostasis, for example serum sodium and glucose levels, and renal function.

Balance between lateral and ventromedial hypothalamic nuclei constitutes a satiety control system.

 Lateral hypothalamic (feeding centre) stimulation leads to overeating

 Lateral hypothalamic destruction leads to lack of interest in food

 Ventromedial hypothalamic (satiety centre) stimulation inhibits eating

 Ventromedial hypothalamic destruction (bilateral) leads to gross obesity.

Serotonin down‐regulates appetite. Selective serotonin reuptake inhibitors (SSRIs) and most antidepressants tend to increase appetite.