Читать книгу Neurology - Charles H. Clarke - Страница 60

I have approached this in two ways. The first is to trace the embryological development of parts of the CNS – and here I have selected the spine and spinal cord, where genes have been identified that deal with either longitudinal or axial spinal development. The second is to illustrate how mutations and other abnormalities translate into neurological diseases. The basic genetics are summarised here, but picked up in the third section of this chapter – in channelopathies. I assume an understanding of Mendelian and mitochondrial inheritance, DNA, RNA, and chromosomes.

Despite the major advances, genetics plays little part in the day‐to‐day neurology of headache, seizures and even conditions such as malignant neoplasms, MS and most cases of Parkinson’s. This may change in years to come.