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Self-emulsifying drug delivery systems are self-emulsifying oil formulations consisting of isotropic mixtures of one or more oil, surfactants, co-surfactant, hydrophilic solvents, and co-solvents and have droplet size in the range of 100 to 300 nm [72]. SEDDS upon mild agitation and dilution with aqueous media form fine oil-in-water (o/w) type self-microemulsifying drug delivery system (SMEDDS) (droplet size of less than 50 nm) [73]. In vivo, the gastrointestinal motility provides the agitation necessary for micro-emulsification and is instrumental in increasing the rate and extent of availability of poorly water-soluble drugs. The physical stability of SEDDS makes them superior to orally administered emulsions; moreover, they can be encapsulated in standard soft gelatin capsules. Further, the SEDDS protect the drug in gut environment and control the release of drugs resulting in improved oral bioavailability [47]. The excipients used in SEDDS have been extensively reviewed by Nardin and Killner [74].