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The transplantation procedures of tissues and organs have limited success rates because of poor availability of donors, high rejection of transplant, and immune reactions to these exogenous bodies. Due to these drawbacks, the focus has shifted to design and synthesis of artificial three-dimensional (3D) scaffolds, which resemble the original biological organs/tissues [86]. Tissue regeneration by using nanoscaffolds loaded with a robust population of specialized cells called stem cells is capable of cell renewal and differentiation, thereby reestablishing disrupted cell functions and structure. Nanoscaffolds are a three-dimensional structure composed of fine biodegradable polymeric fibers, which provide the microenvironment for tissue regeneration by mimicking the behavior of extracellular matrix. Damaged cells also adhere to the scaffold and begin to rebuild tissue through minute pores present in the scaffold. As the tissue grows, the scaffolds are absorbed into the body and disappear completely leaving healthy cells in its place [87].