Читать книгу The SAGE Encyclopedia of Stem Cell Research - Группа авторов - Страница 288

The Notch pathway has been known to developmental biologists for decades. Its role in control of stem cell proliferation has now been demonstrated for several cell types including hematopoietic, neural, and mammary stem cells. Components of the Notch pathway have been proposed to act as oncogenes in mammary and other tumors. A particular branch of the Notch signaling pathway that involves the transcription factor Hes3 has been shown to regulate a number of cultured cells with cancer stem cell characteristics obtained from glioblastoma patients.