Читать книгу The SAGE Encyclopedia of Stem Cell Research - Группа авторов - Страница 295

During embryonic development, syndetome, which is a separate part of the somite, gives rise to progenitor cells that form tendons, aided by the expression of transcription factor scleraxis (SCX). However, the introduction of SCX alone will not result in the formation of tendons or ligaments under laboratory conditions; other factors are required, like SIX1, SIX2, and proteins called Eya, Eya 1, and Eya 2.

The effects of these molecular factors have been studied on animal tendons after trans-section or in injured human tendons, so their role in development is not fully understood. This area of research is creating a lot of interest, as an injured tendon heals with the growth of scar tissue that contains collagen, but the mechanical properties of the healed tendon are never the same as an intact tendon. There is a need to identify the exact mechanisms involved in the development of tendons so injured tendons can be treated with stem cells to gain complete recovery. During embryogenesis, stem cells develop into specialized cells on exposure to specific growth factors. Scientists attempt to create similar conditions for the growth and development of stem cells under laboratory conditions.