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 It has been suggested that commercial plasma leads to fewer adverse side effects than home‐made plasma, although this was not supported by a clinical study in a hospital setting [31].

 Method of plasma preparation could play a role in incidence of adverse effects. Plasma prepared by gravity or centrifuge sedimentation contains a greater amount of cellular material compared to plasma obtained by plasmapheresis. Therefore, the latter preparation method could potentially lead to a lower incidence of immunological reactions [30]. Plasmapheresis is well tolerated by horses and used for collection of plasma without complications but requires specialized equipment.

 Cross‐matching before plasma transfusion would only be able to prevent hemolytic transfusion reactions, which are the result of antibodies in the recipient plasma reacting with the erythrocytes of the donor. This is a very rare occurrence. Cross matching before plasma transfusion is rarely performed.

 Using blood products from a “universal donor” negative for Aa and Qa antigen can help prevent severe reactions. While horses have many different blood antigens, only Aa and Qa are responsible for the majority of severe hemolytic reactions.

 Plasma from geldings or maiden mares is preferred over stallions and mares with prior pregnancies.