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If plasma is homemade (harvested from plasma donors in‐house) care has to be taken to maintain strict asepsis during the procedure. Plasma should be frozen at –18°C or lower within 8 hours post harvesting and stored for a maximum of 1 year at a minimum of –20°C. Aseptic techniques have to be followed during thawing and administration of both commercial and homemade plasma. Plasma should be placed in an additional plastic bag to prevent contamination of the infusion ports if they are exposed. Transfusion should be completed after 4 hours to avoid bacterial contamination. Plasma provides optimal culture conditions for bacteria and once introduced they can proliferate quickly and cause sepsis in the recipient. Clinical signs, diagnosis and treatment of sepsis are not part of this chapter and the reader is referred to other chapters or references.