Читать книгу Gastrointestinal Pathology - Группа авторов - Страница 90

The major differential diagnostic considerations include other types of esophageal mucosal injury that may lead to increased apoptosis, such as drug or infection. Knowledge of the clinical context is important, as epithelial apoptosis in the setting of stem cell transplantation likely represents GVHD, whereas mycophenolate‐associated injury occurs in solid organ transplant recipients. Cytomegalovirus infection also causes apoptosis, and may coexist with GVHD, necessitating immunohistochemical staining for exclusion. In cases where bullae or desquamation is observed endoscopically, the differential diagnosis may also include other vesiculobullous dermatologic disorders involving the esophagus.