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Microscopic Features

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Macrocytic changes and cytologic atypia of squamous epithelial cells and stromal cells are common, often associated with multinucleation and bizarre hyperchromatic nuclei. Notably, the cells maintain an abundant cytoplasm and mitosis is rare. Submucosal fibrosis and obliterative vasculitis may also be evident in deeper biopsy specimens.

Gastrointestinal Pathology

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