Читать книгу Current Concepts in Movement Disorder Management - Группа авторов - Страница 29

The cerebello-thalamo-cortical system (Fig. 1) appears to function largely in parallel with the circuits traversing the basal ganglia. Like the basal ganglia, the cerebellum also receives cortical input, as well as peripheral input (not shown in Fig. 1). The activity of Purkinje cells in the cerebellar cortex is then projected to the deep cerebellar nuclei which, in turn, target cerebellar-receiving areas of the thalamus, specifically the ventral intermedius nucleus (Vim), which, in turn, project to the cerebral cortex (specifically M1). The cerebellar-receiving territory of the thalamus is different from the basal ganglia-receiving territory.

Projections that link the basal ganglia with the cerebellum (via STN projections to the brainstem), and the cerebellum with the basal ganglia (via projections from cerebellar receiving thalamic areas to the basal ganglia) have also been described [2]. The functional relevance of these connections remains unexplored, but they may play a role in the pathophysiology of PD and dystonia, as described below.