Читать книгу Current Concepts in Movement Disorder Management - Группа авторов - Страница 39

It is clear from the above summary of circuit level dysfunction in PD, dystonia, and ET that our knowledge of PD-associated changes is fairly detailed, while it remains rudimentary in the case of dystonia and ET. Gaining further knowledge is highly important for therapy development, and has already resulted in many useful therapeutic strategies, ranging from the use of levodopa and dopamine agonists in PD patients, to deep brain stimulation approaches that appear to be effective for all of the conditions discussed above. Many of the available interventions ameliorate, but do not eliminate the symptoms of the described disorders, and most have undesirable side effects that limit their use. It is hoped that efficacy and side effect profiles of these treatments can be improved through studies that further define the pathophysiology and make possible the rational development of new treatments that more specifically address the pathophysiologic abnormalities. As mentioned before, such treatments may take the form of specific pharmacologic approaches, targeted gene therapy, or the use of novel neuromodulation paradigms, such as feedback-controlled DBS.