Читать книгу Current Concepts in Movement Disorder Management - Группа авторов - Страница 60

In the early stage PD, the aim of the clinical management is to minimize the burden from both motor and nonmotor symptoms of the disease, allowing patients to perform their activities of daily living with minimal functional disability. It is important to acknowledge that even at these stages, a few nonmotor symptoms may precede and accompany the manifestation of motor symptoms, further contributing to the worsening of the quality of life [9]. There are currently three classes of medications used to treat PD at early stages (to be used in either monotherapy or in combination): monoamine oxidase B (MAO-B) inhibitors, dopamine agonists (DAs), and levodopa (combined with either carbidopa or benserazide). Initial treatment choices typically depend on the severity of patient’s symptoms, level of required activity, and age.