Читать книгу Current Concepts in Movement Disorder Management - Группа авторов - Страница 65

Entacapone (a peripheral COMT inhibitor) and tolcapone (both peripheral and central inhibitor) can be used to decrease the off time during the day, allowing and in most times requiring a reduction of daily amount of levodopa. Tolcapone seems to be more potent; however, it is usually used when entacapone is ineffective, since rare cases of hepatotoxicity have occurred, requiring routine monitoring of serum transaminase levels. Additional side effects of both drugs are those related to higher bioavailability of levodopa [7, 8].