Читать книгу Advances in Radiation Therapy - Группа авторов - Страница 26

Possible clinical trial concepts mostly aim at improving local and systemic control in metastatic cancer patients. Taking into account the possible abscopal effect achieved with the combination, radiotherapy of 1 of the metastatic lesions combined with immunotherapy might prolong survival. The concept of radiation achieving an in situ vaccine effect gave rise to the idea of continuing immunotherapy after the development of resistance and progression with radiotherapy to 1 of the progressing lesions. Combining immunotherapy with curative radiotherapy has been discussed for stereotactic ablative radiotherapy of early stage lung cancer in patients carrying a substantial risk for systemic relapse.