Читать книгу Advances in Radiation Therapy - Группа авторов - Страница 34

One of the most interesting imageable biomarkers related to radioresistance is hypoxia, i.e., the lack of oxygen often encountered in solid tumors. Hypoxia is generally referred to as the status when the oxygen level in tissues is below physiological levels. Radiobiological hypoxia usually refers to the very low levels that are required to make cells maximally radioresistant, which is at levels less than 5–10 mm Hg [17]. Hypoxic cells are up to 3 times more radioresistant than normoxic cells, and hypoxia is associated with (radio)therapy resistance and poor prognosis [18]. Therefore, imaging of hypoxia in tumors can be useful in establishing a prognosis, might predict response to (radiation) treatment, and can be used to personalize cancer treatment.