Читать книгу Recent Advances in Dialysis Therapy in Japan - Группа авторов - Страница 57

CMBs are observed as small, round hypointense lesions on gradient-echo T2*-weighted MRI [10]. Previous studies have shown that CMBs occur more frequently in patients with ischemic stroke (IS), transient ischemic attack, and spontaneous ICH [28, 29]. Pathologically, focal hemosiderin deposition has been associated with previous microhemorrhages resulting from bleeding-prone small-vessel diseases, such as hypertensive arteriopathy (including lipohyalinosis and arteriolosclerosis) and cerebral amyloid angiopathy [10]. The prevalence of CMBs is 3.1–23.5% among the healthy population with no cerebrovascular disease [28, 29], 18–68% in patients with IS [29], and 47–83% in patients with ICH [29]. CMBs also predict the future risk of spontaneous ICH and IS in patients after ICH, IS, and transient ischemic attack, as well as in stroke-free individuals [5].

In HD patients, previous reports, including ours, have described a high prevalence of CMBs of 19.3–35% [12, 30, 31], and the presence of CMBs is an independent and strong predictor of ICH but not CI [32].