Читать книгу Gestational Diabetes - Группа авторов - Страница 44

Dietary fatty acid supplementation for improving pregnancy and infant outcomes has been of interest for preterm delivery and infant allergy. The docosahexaenoic acid (DHA) to optimize mother infant outcome trial randomized 2,399 women before 21 weeks gestation to receive DHA-enriched fish oil 800 mg/day or vegetable oil capsules without DHA from randomization until delivery [69]. This study reported no change in risk of GDM or preeclampsia and no differences in infant anthropometry. Long-term follow-up of the children from DHA to optimize mother infant outcome at 7 years showed no difference in anthropometry [70].

In overweight and obese women, undergoing in vitro fertilization, those women with higher omega 6 PUFA and linoleic acid intakes in their diet were more likely to become pregnant [71]. A randomized blinded trial of 72 overweight or obese women allocated to omega 3 fatty acid supplementation with DHA plus eicosapentaenoic acid (2 g/day) or placebo twice a day from week 10 to 16 to the end of pregnancy reported a reduction in inflammatory markers in maternal plasma, adipose tissue, and placenta [72]. Clinical outcomes were not reported.