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Lipid nanoparticles are colloidal particles ranging in size from 10 to 1,000 nm. Currently, there are two generations of lipid nanoparticles: SLNs and NLCs. SLNs can be considered as the first generation of lipid nanoparticles, whereas NLCs are regarded as the second generation, overcoming the shortcomings of SLNs [47, 52, 53] (Table 2).