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NLCs are second-generation lipid nanoparticles [60]. They are modified forms of SLNs in which the lipid phase is comprised of both liquid lipids and solid lipids. NLCs were developed to overcome some of the challenges with SLNs, such as particle agglomeration, drug leakage, risk of gelation, high water content, and poor drug loading. The addition of liquid lipids to the structure of NLCs led them to have a higher drug-entrapment potential, higher skin-permeation potential, and lower occlusive capacity when compared to SLNs [61]. The mechanism of skin permeation of NLCs is similar to SLNs. Since NLCs have a higher drug loading capacity, a higher concentration gradient can be achieved as compared to SLNs. The use of NLCs in physical sunscreen has been found to have synergistic UV protection properties. All these attributes make NLCs excellent carriers for topical drug delivery to improve skin hydration, controlled drug release, drug permeation, and drug stability [62]. NLCs have been successfully utilized in the topical delivery of photolabile antioxidants like alpha-lipoic acid and topical retinoids [62–65].