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The permissible limit of Mn in drinking water given by WHO (2011) and BIS (2012) is 300 and 100 μg/L, respectively. Inhalation or contact with a higher concentration of Mn can cause damage to the central nervous system (Singh et al. 2011). It can readily accumulate in the brain, particularly in the basal ganglia, and can result in an irretrievable neurological syndrome like Parkinson's disease. Comparatively higher doses of manganese affect DNA replication and lead to mutations in the microorganism and mammalian cells. In mammalian cells, manganese causes DNA impairment and chromosome abnormalities. The higher concentration of it affect fertility in mammals and are deadly to the embryo and foetus (Singh et al. 2011).