Читать книгу Pathology of Genetically Engineered and Other Mutant Mice - Группа авторов - Страница 100

In male mice, infertility is often a consequence of defective biogenesis or function of the motile spermatozoal flagellum [39]. Many flagellar defects are visible by light microscopy [40] and may be accompanied by other lesions commonly associated with dysfunctional motile cilia [41] (Figure 6.3). In contrast, fertility is generally not impaired in female mice with motile cilia deficiencies, despite the presence of ciliated epithelium of the oviduct. These findings are consistent with those in humans with PCD, where reduced fertility in men with PCD is attributed to dysmotility of spermatozoa and/or reduced sperm count, while lack of ciliary motility in the Fallopian tubes of women does not appear to have a major effect on fertility [42]. Although cilia‐related infertility is usually associated with dysfunctional motile cilia, defective immotile sensory cilia are also involved in some cases [43].

Figure 6.3 Epididymis. Flagellar defects or dysfunction are common causes of male infertility.