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Pathology of Genetically Engineered and Other Mutant Mice
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Страница 1
Table of Contents
List of Tables
List of Illustrations
Guide
Pages
Страница 7
Страница 8
Страница 9
Страница 10
1 Introduction to Mouse Pathology
The Use of Mice in Medical Research
Understanding Diseases Found in Mutant Animals
Mouse Pathology – Nomenclature
Mouse Genetic Nomenclature
Tumor Pathology
Immunohistochemistry (IHC), Scoring, Image Analysis, and Other Supportive Research Pathology Techniques
Publication of Erroneous Pathology Data: Inadvertent Fraud?
Overall Organization of the Book
Acknowledgments
References
2 The Mouse Online: Open Mouse Biology and Pathology Data Resources for Biomedical Research:
Introduction
FAIR Data Access and Databases of Databases
General Information on Inbred Laboratory Mice Mouse Genome Informatics (
http://www.informatics.jax.org
)
MouseMine (
http://www.mousemine.org/mousemine/begin.do
)
Monarch (
https://monarchinitiative.org
)
Alliance of Genome Resources (
https://www.alliancegenome.org
)
Mouse Models of Human Cancer Database (MMHC, Formerly Mouse Tumor Biology Database) (
http://tumor.informatics.jax.org/mtbwi/index.do
)
Mouse Genome Informatics SNP Database (
http://www.informatics.jax.org/snp
)
Sanger Mouse SNP Database (
https://www.sanger.ac.uk/sanger/Mouse_SnpViewer/rel‐1505
)
Large Scale Mutagenesis International Mouse Phenotyping Consortium (IMPC;
https://www.mousephenotype.org
)
MUTAGENETIX (
https://mutagenetix.utsouthwestern.edu
)
Background Strain Comparison Studies Mouse Phenome Database (
https://phenome.jax.org
)
Mouse Pathology Image (Histopathology) Resources Pathbase, the European Mouse Pathology Database (
http://www.pathbase.net
)
National Toxicology Program Neoplastic Lesion Atlas (
https://ntp.niehs.nih.gov/nnl/index.htm
)
Noah's Arkive, Charles Louis Davis, and Samuel Wesley Thompson Foundation for the Advancement of Veterinary and Comparative Pathology (
http://noahsarkive.cldavis.org/cgi‐bin/show_image_info_page.cgi
)
Organ/Disease Specific Resources
Bone Diseases: Skeletal Phenotyping of IMPC/KOMP Mice (
http://www.bonebase.org
)
Skin Diseases: Skinbase (http://eulep.pdn.cam.ac.uk/~skinbase/index.php)
GenitoUrinary Development Molecular Anatomy Project (GUDMAP) (
https://www.gudmap.org
)
Mouse Brain Atlas (
https://developingmouse.brain‐map.org
,
https://mouse.brain‐map.org
)
Atlas of Mouse Cardiovascular Development (
https://www.devbio.pitt.edu/research/atlas‐mouse‐cardiovascular‐development
)
Mouse/Human Disease Phenotype Databases
Online Mendelian Inheritance in Man (OMIM) (
https://www.ncbi.nlm.nih.gov/omim
)
Emouseatlas (
https://www.emouseatlas.org/emap/home.html
)
Finding Mouse Models
Use of Mouse Pathology Resources on Line; Citations, and Licenses
Acknowledgments
References
3 Mouse Genetic Nomenclature: The Underpinning of Mouse Genetics
Introduction
Why Use Standardized Nomenclature?
Inbred Mice
Hybrid Mice (F1 and F2)
Recombinant Inbred (RI) and Recombinant Congenic Mice
Collaborative Cross (CC) Mice
Congenic Mice
Consomic Mice
Conplastic Mice
Outbred Mice
Diversity Outbred (DO) Mice
Nomenclature for Normal and Mutated Genes
Spontaneous Mutations in Mice
Non‐engineered Induced Mutations
Chromosomal Aberration Nomenclature
Genetically Engineered Mice
Targeted, Endonuclease‐Mediated, Enhancer or Gene Trap, Transposon‐Induced, and Transgenic Mutations
Summary
Acknowledgments
References
4 Discovering and Validating Mouse Models of Human Diseases: The Cinderella Effect
Introduction
Basic Concepts of Defining a Mouse Model for a Human Disease
Large‐Scale Mutagenesis Projects to Discover New Mouse Models
From Human Polymorphism to Mouse Models
New Mouse Genetic Tools
Patient Derived Xenograft (PDX) Models
Acknowledgments
References
5 Embryos, Placentas, and Neonates
Introduction
Four‐Dimensional Anatomy of the Developing Mouse
Developmental Events in Embryos and Neonates
Developmental Events in Placentation
Technical Considerations for Pathologic Evaluation of Developing Mice
Noninvasive Imaging of Developing Mice
Anatomic Pathology Evaluation ofDeveloping Mice
Clinical Pathology Evaluation of Developing Mice
Pathologic Patterns in Mouse Embryos and Neonates
Pathologic Patterns in Mouse Placenta
Summary
References
6 Ciliopathies
Introduction
Motile Ciliopathies
Rhinosinusitis and Otitis Media
Hydrocephalus
Laterality Defects
Infertility
Sensory Ciliopathies
Cystic Kidney Diseases
Retinal Degeneration
Heart Defects
Skeletal Defects
Brain Malformations
Deafness
Anosmia
Obesity
Genetic Background Effects
References
7 Hematopoietic and Lymphoid Tissues
Introduction
Bone Marrow
Lymphoid Tissues
Primary Lymphoid Organs
Thymus
Secondary Lymphoid Organs Lymph Nodes
Mucosa‐Associated Lymphoid Tissues
Spleen
Milky Spots
Tertiary Lymphoid Organs
Acknowledgments
References
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