Читать книгу Pathology of Genetically Engineered and Other Mutant Mice - Группа авторов - Страница 25

The Mouse Genome Informatics (MGI) international database resource is the most comprehensive collection of information on mouse biology available today. It is the first place one should go to when searching for information on the mouse or even just searching for a mouse. MGI is an integrated collection of databases providing access to comprehensive information on genetics, genomics, and biology of the laboratory mouse. Data in MGI are obtained by direct expert curation of published literature and importation of large‐scale datasets from other data resources. The Mouse Genome Database (MGD) [4] is the core resource for general mouse information in MGI. MGD contains information on mouse genes, strains, phenotypes, mutant alleles, sequences/single nucleotide polymorphisms (SNP), vertebrate homology, and mouse models of human disease. MGD also is the source for official gene, allele, and mouse strain nomenclature using International Committee on Standardized Nomenclature for Mice standards (see Chapter 3 for details on nomenclature). The GXD [5] contains information on gene expression in the developing mouse including immunohistochemistry, immunofluorescence, and in situ hybridization images. The CrePortal contains data on cre‐recombinase expressing mice with a large library of images [6]. The Gene Ontology (GO) project provides functional annotations for mouse gene products [7–11]. The Mouse Models of Human Cancer database (MMHC) contains information on inbred mouse strains, genetically engineered mouse (GEM) models, [12–15] and patient derived xenograft (PDX) models of human cancer [16]. This database is particularly useful for pathologists and is described in detail below. Databases in the MGI consortium that contain images are the MGD, the MMHC, and the GXD.