Читать книгу Pathology of Genetically Engineered and Other Mutant Mice - Группа авторов - Страница 23

Large collections of data and resources are available online, ranging from genomic and gene expression databases (GXDs) to archives of experimental data, phenotype data, and bioresources such as strains, cell lines, and tissues. While many core resources contain multispecies data and are good sources for mouse information, this review will cover some of the major websites that provide access to mouse‐centric databases (Table 2.1) and how they can be used to assist with analysis of normal, abnormal, or mutant mice.

Databases fall into two main categories; those where data are gathered, expertly curated, and presented by the database project itself, often integrating data from several sources and analytical tools. The second type of database acts as an archival platform to which data are uploaded by users, often with minimal curation. There are several examples of hybrids of various proportions where uploads are solicited by the database, curated to a different degree, and presented with core data sourced and validated by the database staff. Curated databases may also be long‐term repositories or archives of legacy datasets. Data resources are generally funded out of project/program grants and core institutional funding. The degree of currency and the depth of curation often depends on funding and funding sustainability. Metrics and indicators for database description, and to a degree for assessing database quality, can be found in ELIXIR [1], as the criteria developed for qualification as an ELIXIR core database are widely applicable. A good source of rapidly accessible core information about databases is the annual database issue of Nucleic Acids Research. Databases present their core activities and modes of access in the papers but also publish updates as significant developments are achieved. It is always useful to browse this issue when looking for new sources of data.