Читать книгу Pathology of Genetically Engineered and Other Mutant Mice - Группа авторов - Страница 35

Pathbase is a community resource for images of all types of lesions and normal tissues from laboratory mice [57, 58]. Pathologists from all over the world, not just Europe, provide photomicrographs of lesions diagnosed in laboratory mice. While initially the goal was to illustrate lesions in genetically engineered mice, this website has evolved to include all types of mouse diseases as well as normal tissues including large collections of images from aged inbred mouse strain studies [33]. These data are curated in an ontology built around the Mouse Anatomy (MA) [59] and Mouse Pathology (MPATH) [60] ontologies, with more refinement for selected organs, such as skin [61]. This enables rapid retrieval of histologic images. In fact, if one integrates this into a diagnostic database, one can use the diagnostic term to go to Pathbase to look up the definition of the term and then access images of lesions with that diagnosis provided by numerous pathologists from around the world, something called the “virtual second opinion” [62]. Integration of the Mouse Anatomy and Pathology Ontologies into diagnostic laboratory software sets up a controlled vocabulary that enables consistent data searches to enable high‐level computational analysis of the dataset [62, 63].