Читать книгу Pathology of Genetically Engineered and Other Mutant Mice - Группа авторов - Страница 36

The National Toxicology Program Atlas of Nonneoplastic Lesions in Rats and Mice is a publicly accessible resource built around the goal of identifying potential human carcinogens in rodent bioassays. Nonneoplastic diseases are also a major cause of morbidity and mortality in humans. This atlas provides diagnostic guidelines for histologic lesions in both rats and mice. This was built around an effort to maintain consistency with lesion terminology through the creation of the International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) monograph series [64, 65] and classification systems in textbooks [66, 67]. A web resource for INHAND can be found on https://www.toxpath.org/inhand.asp.

The database is organized by major organ systems (alimentary, cardiovascular, endocrine, hematopoietic, hepatobiliary, immune, integumentary, musculoskeletal, nervous, reproductive [female and male], respiratory, special senses, and urinary) and within each category are a limited number of examples of lesions with a representative image. This is useful for getting started to gain a basic understanding of lesions, terms, and definitions. Unfortunately, while aimed at standardizing toxicology diagnoses, it does not embrace the complexity of human disease making it relatively superficial and not helpful to define a mouse model for a human disease.