Читать книгу Pathology of Genetically Engineered and Other Mutant Mice - Группа авторов - Страница 29

The Mouse Models of Human Cancer Database is one of the core databases included in the MGI consortium. Unlike Pathbase (see below), which covers all types of lesions diagnosed in laboratory mice, this website focuses on cancer and hyperplastic lesions in mice (Figure 2.2). Much of the database is built around data and the literature such that the images are supplemental to the enormous amount of data on strain specific lesions, genes known to cause specific types of cancer, and how this information relates to human cancer [12,24–29]. A recent change has been to integrate photomicrographs of human cancers into the database for more direct anatomic comparisons. Also, MMHC contains datasets and webpages focused on specific topics, such as skin cancers [15], lymphomas [13], and a list of antibodies tested in mice with conditions tested under and results [30]. Whole slide scanned images of the lymphomas with immunohistochemistry demonstrate how to subtype the lesions can be accessed in this database [13]. The lymphoma digital slide (whole slide images) collection originates from the NCI Mouse Models of Cancer Consortium workshop on Hematopoietic Tumors (http://tumor.informatics.jax.org/mtbwi/lymphomaPathology.jsp) [31, 32]. Lung cancers and hyperplasias were whole‐slide scanned from a large‐scale aging program looking at lesions in 31 inbred mouse strains [33, 34]. Current projects include developing a training module to aid pathologists in the interpretation and grading of non‐melanoma skin cancers in mice caused by UV light, two‐stage chemical carcinogenesis, papillomavirus, or those that arise in production colonies spontaneously. As PDX (cancers resected from patients and transplanted into immunodeficient mice) have become a major research tool, these too are included in this database [16].

The histopathology images included in MMHC are curated from the primary literature, when given permission by the publisher, and from direct submissions from researchers and large‐scale projects.

As of January 2020, MMHC contains over 6400 photomicrographs, both histological and immunohistochemical. These images are attached to detailed information on the tumor diagnosis, strain, genetics, original reference, treatment, and human lesion the strain models. Images also contain annotations from the submitting author/pathologist if the image is a direct submission or notes from the curated reference that are relevant to the image.