Читать книгу Pathology of Genetically Engineered and Other Mutant Mice - Группа авторов - Страница 39

The Knockout Mouse Program (KOMP) is a United States initiative in collaboration with the International Knockout Mouse Consortium (IKMC) to generate a large number of laboratory mice with a single gene inactivated (null mouse) eventually for all protein coding genes, one at a time. A collaboration between investigators at several institutions have been systematically analyzing bones in C57BL/6NJ mice generated by KOMP. This is not one of the primary sites generating and phenotyping these mutant mice, but rather a group specializing in detailed analysis of subtle abnormalities only of bones. The group is focused on screening gene knockout mice for variation in bone mass using μCT and histomorphometry to systematically analyze mice generated from the various KOMP primary sites [68].