Читать книгу Pathology of Genetically Engineered and Other Mutant Mice - Группа авторов - Страница 12

There has been a large increase in the use of mice in both basic and translational medical research over the past 20 years, as evidenced by the increase in retrievable references using “mice” as a keyword in PubMed from 29 029 publications in 1998 to 79 858 in 2018, and over 1.6 million in the entire PubMed database. Mice have been used for both basic and translational (formerly applied) research. Much of this important work is sponsored by the National Institutes of Health (NIH) in the United States. Mice have been used to study basic biological processes, embryo development, genetic disorders, infectious diseases, degenerative diseases, toxicology, carcinogenesis, and aging, often by organ system or tissue. Many Nobel Prize awardees in Physiology or Medicine have used mice in research leading to their honors. Much of this research has been greatly valued for the training of future scientists, discovery of new diseases, understanding the mechanism of disease in mice and other animals, including humans, and in the treatment and prevention of disease in mice and humans [1–8]. Histopathology may be included in the mouse research, but often it is not, or not by someone trained and competent in pathology [9]. The value of pathology has been proven for diagnosis and understanding normal biology and abnormal biology (pathology) of cells, tissues, and organs in all species. Comparative pathology spans all species of animals. But some investigators do not understand the value of pathology, as a discipline, in experimental studies with mice. This book intends to promote the value of mouse pathology in medical research aimed at the discovery of the causes, prevention, and therapy of diseases in both humans and other animals.