Читать книгу Pathology of Genetically Engineered and Other Mutant Mice - Группа авторов - Страница 16

It is known in human and mouse pathology that cancer pathogenesis follows a scheme of molecular pathogenesis and an associated histopathogenesis [14, 16, 36]. There have been numerous publications on the role of specific genes in tumor pathogenesis in humans and animals. It is not the intention of this book to review the role of all genes for which published information on mouse cancer models is available, but rather to provide samples of some of the more common and important genes that play important roles. GEM may involve a single gene and attempt to mimic the human genetic disorder, or GEM may represent non‐familial genetic changes in the pathways to disease including cancer. Tumor frequency data in wild‐type control mice, especially in aging studies, have often been reported in various strains and stocks [1, 7, 23, 35, 37, 38]. While these reports provide general background information on the frequency of cancer types in a wildtype inbred strain, the actual frequency will vary based on substrain, husbandry, and other factors, necessitating the use of adequate numbers of control mice for studies on frequency of cancers in GEMs.