Читать книгу Pathology of Genetically Engineered and Other Mutant Mice - Группа авторов - Страница 82

Comparative pathologists who evaluate adult mice can phenotype developing mice as well. However, new practitioners will need to attain familiarity with unusual anatomic features, physiological processes, and lesion patterns that are the norm in embryos and neonates. Most investigators approach histopathological evaluation of late‐stage embryos (gestational day [GD] 15.5 or older), neonates, and juveniles (up to postnatal day [PND] 42) with confidence due to anatomic similarities between these developmental stages and adult mice. This assurance fades when the rapidly evolving morphology of earlier embryos and their extra‐embryonic membranes needs to be characterized.

This chapter offers a brief introduction to key anatomical and pathophysiological concepts in prenatal and early postnatal mice. More detailed coverage of specific mouse developmental anatomy and pathology topics is available in other books [1–5], book chapters [6–9], anatomic atlases [10–15], major review articles [16–27], and websites [15,28–30].