Читать книгу Pathology of Genetically Engineered and Other Mutant Mice - Группа авторов - Страница 78

Mouse cancer models, be they spontaneous, induced by a variety of means, or genetically engineered, have been invaluable as tools to dissect underlying mechanisms of disease. However, they have had a smaller impact on translational studies to directly impact cancer treatment in humans. Development of refined immunodeficient mouse models [64, 91] has enabled engraftment of human cancer cells into these mice providing a tool to directly assess the human cancers in this xenograft model. These patient derived xenografts (PDX models) are used for target‐validation and drug‐assessment studies [92].