Читать книгу Pathology of Genetically Engineered and Other Mutant Mice - Группа авторов - Страница 77

The power of mouse genetics is being increasingly exploited, for example by using the resources of inbred strains which are now being used to construct genetic reference populations, such as the Collaborative Cross [86], which mimics the genetic complexity of human populations and the Diversity Outcross mice, a stock of truly outbred mice derived from the incipient inbred collaborative cross strains [87], that can provide defined heterozygosity. Together with the ability to manipulate the genome through reverse genetics, these novel mouse genetic tools provide complementarity to human clinical and genetic studies never before available. Medicine will continue to face major challenges for which mouse models will prove to be invaluable; for example, the ability to predict whether a particular individual will develop one or more of hundreds of different diseases for which they carry predisposing alleles, the accurate prediction of risk or prognosis or a particular disease in an individual and the prioritization of the many candidate genes arising from GWAS studies [88–90]. Success in translational research depends on the combined efforts of investigators in the laboratory and clinic to create the ideal slippers (mice) for Cinderella to go to the Ball.