Читать книгу Pathology of Genetically Engineered and Other Mutant Mice - Группа авторов - Страница 60

Conplastic strains have been created by backcrossing the nuclear genome from one inbred strain into the cytoplasm of another in which the mitochondrial parent is always the female parent during the backcrossing program. The strain designation is the nuclear genome strain‐mt^{cytoplasmic genome strain}. For example, C57BL/6J‐mt^A/J/Na is a strain with the nuclear genome derived from C57BL/6J and the cytoplasmic genome from A/J, which was created by crossing male C57BL/6J mice with A/J females [32]. Their female progeny were repeatedly backcrossed to male C57BL/6J. As with congenic strains, a minimum of 10 backcross generations are required.