Читать книгу Pathology of Genetically Engineered and Other Mutant Mice - Группа авторов - Страница 108

The primary cilia projecting from the surface of the olfactory epithelium utilize GPCRs on the ciliary membrane to detect and transduce signals from odorants [88]. The dysfunction or mislocalization of ciliary proteins and/or the loss of cilia will prevent olfaction [89], and mice lacking functional cilia on their olfactory neuroepithelium are anosmic [90]. Certain types of inherited anosmias may be accompanied by severely reduced ciliated borders over the olfactory neuroepithelium [91], but most defects involving the structure or signaling functions of olfactory receptors are not detectable by light microscopy or associated with degeneration or apoptosis of olfactory sensory neurons [89].