Читать книгу Manual of Equine Anesthesia and Analgesia - Группа авторов - Страница 105

 Most drugs used for sedation/tranquilization and anesthesia cause some degree of dose‐dependent cardiovascular changes which may manifest as changes in HR, preload, afterload, contractility or a combination of these factors.

 Regardless of which drugs are used, drug dosages in compromised patients should almost always be reduced.Most adverse effects, like the cardiovascular depression caused by inhalational anesthetic gases, are dose‐dependent.A greater percentage of administered drug may reach the brain (see below).