Читать книгу Manual of Equine Anesthesia and Analgesia - Группа авторов - Страница 221

 In the horse, the effects of sedatives on lung function are relatively minor although differences do exist among agents.

 In general, with acepromazine and α2 adrenergic agonists, ventilation changes include a decrease in rate and an increase in tidal volume.

 α2 agonists increase the work of breathing.Due to a decrease in tone of the abductor muscles of the upper respiratory tract, thus leading to collapse of the external nares and/or laryngeal structures during inspiration.The effects of increased work of breathing are insignificant in the normal horse, but may be significant in the horse with airway obstruction.Heavy sedation with α2 agonists (e.g. detomidine 0.01 mg/kg, IV) decreases the gas exchange function of the lungs.The decrease in oxygenation with detomidine sedation is due, in part, to an increase in the V/Q maldistribution within the lung.