Читать книгу Manual of Equine Anesthesia and Analgesia - Группа авторов - Страница 295

 Renin is synthesized by myofibroblast‐like cells located in the renal afferent arterioles.These cells are commonly referred to as juxtaglomerular cells.

 The primary physiologic triggers for renin release are:Decreases in extracellular fluid volume.Sodium depletion.Prostaglandins.Hypotension (MAP < 80 mmHg).Increases in sympathetic output.

 The factors inhibiting renin release are:Angiotensin II.Atrial natriuretic peptide.Vasopressin.

 Renin converts angiotensinogen (a protein synthesized by the liver) to angiotensin I.This is the rate‐limiting step of the RAAS.