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A Osmotic diuretics (e.g. mannitol)

Оглавление

 Inhibit water and sodium reabsorption predominantly at the PCT with some effects on the descending LOH and collecting duct.

 Expand extracellular fluid and plasma volume, increasing RBF.This will lead to medullary washout and an inability to concentrate urine.

 They are filtered through the glomerulus and increase osmotic pressure in the tubule. This reduces transmembrane water flow.

Note: glucosuria will also induce an osmotic diuresis.

Manual of Equine Anesthesia and Analgesia

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