Читать книгу Manual of Equine Anesthesia and Analgesia - Группа авторов - Страница 317

 Acetazolamide is highly protein bound and is not filtered by the glomerulus.It is secreted by the proximal tubule.Secretion is GFR dependent.

 It inhibits the activity of membrane and cytoplasmic carbonic anhydrase in the PCT, preventing reabsorption of bicarbonate. This results in decreased activity of the Na+/H+ exchanger, causing more sodium to remain in the filtrate.

 Increases renal excretion of Na+, K+, HCO3−.

 Results in a proximal renal tubular acidosis.

 Can cause metabolic acidosis.Hence, its potential use as a treatment for metabolic alkalosis.

 Other clinical uses of acetazolamide include glaucoma and neurologic disorders.

 In equine practice, their main use is in horses likely to be affected by a hyperkalemic periodic paralysis (HYPP) episode.