Читать книгу Manual of Equine Anesthesia and Analgesia - Группа авторов - Страница 320

 This group of diuretics is rarely used in horses.

 Thiazides inhibit the Na+/Cl− cotransporter in the DCT, decreasing sodium reabsorption.

 However, this transporter is only responsible for reabsorbing about 5% of the filtered sodium.Thus, thiazides are not as effective as loop diuretics in promoting diuresis and natriuresis.However, like loop diuretics, part of the loss of H+ and K+ is due to activation of the RAAS.This can result in K+ loss leading to hypokalemia.