Читать книгу Pathy's Principles and Practice of Geriatric Medicine - Группа авторов - Страница 148

Progressive impairment of the oxidative balance, consisting of increased production of reactive oxygen species (e.g. superoxide anion radical, nitric oxide) and reduced antioxidant defences, can occur in neurons. In turn, this can promote and sustain the accumulation of dysfunctional and aggregated proteins and mitochondria. Moreover, it can lead to a dysfunction of proteasome and lysosome and, ultimately, to global cellular damage.^23,25