Читать книгу Pathy's Principles and Practice of Geriatric Medicine - Группа авторов - Страница 150

The ability of neurons to control Ca²⁺ dynamics is compromised during ageing. Aberrant levels of cytoplasmatic calcium can produce a dysregulation of protein phosphorylation, gene expression, and cytoskeletal function. Moreover, the loss of calcium homeostasis can lead to the activation of proteases and promote caspase‐dependent apoptosis, resulting in neuronal death (calcium‐mediated excitotoxicity).^23,27