Читать книгу Pathy's Principles and Practice of Geriatric Medicine - Группа авторов - Страница 149

The ability to remove damaged and dysfunctional molecules by proteasomes and lysosomes is crucial for neurons, given their post‐mitotic status. Nevertheless, the autophagic and proteasomal degradation processes are impaired during ageing. This can result in the intraneuronal accumulation of autophagosomes/autophagic vesicles with undegraded cargos, organelles, and polyubiquitinated proteins.^23,26