Читать книгу Pathy's Principles and Practice of Geriatric Medicine - Группа авторов - Страница 151

The main neuronal signalling pathways responding to and mitigating cellular (e.g. metabolic, ionic, oxidative) stresses may become impaired with ageing.^23,28 For instance, the adaptive pathways mediated by neurotrophic factors (e.g. brain‐derived neurotrophic factor [BDNF], nerve growth factor [NGF]), calmodulin‐dependent transcriptions factors, and nitric oxide are perturbed or compromised, thus rendering neurons more vulnerable to damage and death.²³